Publications

HELB is a feedback inhibitor of DNA end resection. Molecular Cell (2016)

Tkac J*, Xu G*, Adhikary H, Young JTF, Escribano-Diaz C, Krietsch J, Orthwein A, Munro M, Sol W, Al-Hakim A, Lin ZY, Jonkers J, Piet B, Gingras AC, Rottenberg S, Masson JY, Durocher D. (* co-first authors)

Article 

A mechanism for the suppression of homologous recombination in G1 cells. Nature (2015)

Orthwein A*, Noordermeer S*, Wilson MD, Landry S, Enchev RI, Sherker A, Munro M, Pinder J, Salsman J, Dellaire G, Xia B, Peter M, Durocher D. A mechanism for suppression of homologous recombination in G1 cells. Nature in press. (* co-first authors)
Article

HSP90 inhibitors decrease AID levels and activity in mice and human cells. Eur J Immunol (2015)
Montamat-Sicotte D, Safavi S, Abreu C, Litzler LC, Zahn A, Orthwein  A, Muschen M, Oppezzo P, Munoz DP, Di Noia JM. (* co-first authors)
Article

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5’ end resection. Nature (2015)
Boersma V*, Moatti N*, Segura-Bayona S, Peuscher MH, van der Torre J, Wevers BA, Orthwein A, Durocher D, Jacobs JJL. (* co-first authors)
Article

Mitosis inhibits DNA double-strand break repair to guard against telomere fusions. Science (2014)
Orthwein A, Fradet-Turcotte A, Canny MD, Brun C, Strecker J, Escribano-Diaz C, Durocher D.
Article

53BP1 is a reader of the DNA damage-induced H2A Lys15 ubiquitin mark. Nature (2013)
Fradet-Turcotte A, Canny MD, Escribano-Diaz C, Orthwein A, Leung CC, Huang H, Laundry MC, Kitevski-Leblanc J, Noordermeer S, Sicheri F, Durocher D.
Article

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Molecular Cell (2013)
Escribano-Diaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkac J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D, Durocher D.
Article

Activation induced deaminase: how much and where? Semin Immunol (2012)
Orthwein A, Di Noia JM.
Article

Moduler la diversification des anticorps pour combattre certaines maladies. Médecine Sciences Amérique (2012)
Orthwein A, Di Noia JM.
Article

Optimal functional levels of activation-induced deaminase specifically requires the Hsp40 DnaJa1. EMBO J (2012)
Orthwein A, Zahn A, Methot S, Godin D, Conticello S, Terada K, Di Noia JM.
Article

Regulation of AID stability and antibody gene diversification by Hsp90. J Exp Med (2010)
Orthwein A, Patenaude AM, Affar EB, Lamarre A, Young JC, Di Noia JM.
Article

Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nat Struct Mol Biol (2009)
Patenaude AM, Orthwein A, Hu Y, Campo VA, Kavli B, Buschiazzo A, Di Noia JM.
Article

Productive HIV-1 assembly takes place at the plasma membrane. J Virol (2007)
Finzi A, Orthwein A, Mercier J, Cohen EA.
Article